Physiologic modelling of MM creatine kinase isoforms
نویسندگان
چکیده
منابع مشابه
The nature of post-translational formation of MM creatine kinase isoforms.
Isoforms (derived from the same isoenzyme but distinguished by differences in isoelectric point) of MM creatine kinase appear in plasma after myocardial infarction. They are formed by conversion of the tissue form of creatine kinase (MM-A, pI 7.80) to progressively more acidic species (MM-B, pI 7.50) and MM-C (pI 7.20) after release into the circulation. To define the changes responsible for my...
متن کاملEarly detection of myocardial reperfusion by assay of plasma MM-creatine kinase isoforms in dogs.
To determine whether myocardial reperfusion can be detected promptly by changes in profiles of isoforms of MM-creatine kinase (CK) in plasma, coronary occlusion was induced in 30 conscious dogs and reperfusion was initiated after 1, 2, 3, or 4 hr in 21. The myocardial isoform of MM-CK, MMA, was quantified in serial plasma samples by chromatofocusing. Before coronary occlusion, MMA comprised 13 ...
متن کاملREPERFUSION Early detection of myocardial reperfusion by assay of plasma MM - creatine kinase isoforms in dogs *
To determine whether myocardial reperfusion can be detected promptly by changes in profiles of isoforms of MM-creatine kinase (CK) in plasma, coronary occlusion was induced in 30 conscious dogs and reperfusion was initiated after 1, 2, 3, or 4 hr in 21. The myocardial isoform of MM-CK, MMA, was quantified in serial plasma samples by chromatofocusing. Before coronary occlusion, MMA comprised 13 ...
متن کاملCreatine kinase isoforms in ischemic heart disease.
The MM and MB isoenzymes of creatine kinase exist in serum as a collection of at least three major MM and two major MB isoforms. Each of these are derived from single tissue MM and MB isoforms, which are converted to these other forms by carboxypeptidase N after their release from necrotic skeletal and myocardial tissue. Measurement of the MM isoforms in ischemic heart disease is useful for ear...
متن کاملAbnormal electrophoretic mobility of a creatine kinase MM isoenzyme.
The routine determination of creatine kinase (CK; EC 2.7.3.2) isoenzymes has recently gained acceptance as a diagnostic tool in laboratory medicine (13). Electrophoreticaily three distinct CK isoenzymes can be separated (4, 5). These dimeric bands have been identified throughout the literature as MM, MB, and BB, and originate mainly from skeletal muscle, heart, and brain tissues, respectively. ...
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ژورنال
عنوان ژورنال: Mathematical and Computer Modelling
سال: 1988
ISSN: 0895-7177
DOI: 10.1016/0895-7177(88)90567-5